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Biology not physics holds the key to reality

Article Stuart Kauffman, Andrea Roli Theory 2025

Three centuries after Newton framed reality in fixed laws and deterministic equations, science has reached a radically new frontier, argue biochemist and complex systems theorist Stuart Kauffman and computer scientist Andrea Roli. The biosphere – life’s evolving web – is not a clockwork mechanism but a self-creating, unpredictable system. Organisms constantly repurpose their worlds in ways that cannot, even in principle, be foreseen or captured in a mathematical framework. Science must now confront a bold idea: reality is not fully governed by any law – and biology, not physics, holds the key to its deeper mysteries.

Three centuries after Newton taught us to see the universe as a clockwork governed by universal laws, Stuart Kauffman and Andrea Roli invite us to a third revolution: biology, not physics, may hold the key to deeper reality.

They argue that the biosphere is not a deterministic mechanism, but a system of ongoing innovation, where new “relevant variables” emerge, vanish, and reconfigure the very space of possibility.

In plain terms: in biology, we cannot always predict what will evolve next, because evolution changes the game itself. The rules shift, new players enter, old ones leave. Hence, any attempt to embed life into a fixed mathematical framework (as physics does) is bound to fail.

What this means (to me):

  1. Unpredictability is essential. Some of the deepest truths about life might forever elude being “solved” via fixed equations.

  2. Creativity matters in nature. Living systems constantly innovate and co-create.

  3. Our worldview may shift: physics may reveal one layer of how things can behave, but biology shows how things become, and in that becoming, we glimpse the essence of complexity itself.

I believe, seeing life this way helps us understand complexity collectively, weaving it into how we learn, how we work, and how we collaborate at every level. By understanding biology (and, in the wider sense, nature and Life) we also begin to understand the world we inhabit with greater responsibility.

From summary here

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